Association of a Multiancestry Genome-Wide Blood Pressure Polygenic Risk Score With Adverse Cardiovascular Events.

Vibhu Parcha Akhil Pampana Naman S ShettyMarguerite R IrvinPradeep Natarajan Henry J Lin Xiuqing Guo Stephen S Rich Jerome I Rotter Tanja Dudenbostel Suzanne OparilGarima AroraPankaj Arora

Published in: Circulation. Genomic and precision medicine (2022)

In a multiancestry cohort of >21 000 US adults, genome-wide SBP PRS was associated with BP traits and adverse cardiovascular events. Adequate control of modifiable cardiovascular risk factors may reduce the predisposition to adverse cardiovascular events among those with a high SBP PRS.

Keyphrases

cardiovascular events
genome wide
cardiovascular risk factors
cardiovascular disease
coronary artery disease
dna methylation
blood pressure
copy number
adverse drug
metabolic syndrome
type diabetes
gene expression
hypertensive patients
emergency department
weight loss