Serine proteases as luminal mediators of intestinal barrier dysfunction and symptom severity in IBS.

Shoko EdogawaAdam L EdwinsonStephanie A PetersLakshmikanth L ChikkamenahalliWendy SundtSara GravesSakteesh V GurunathanMargaret Breen-LylesStephen JohnsonRoy DyerRondell GrahamJun ChenPurna C Kashyap Gianrico Farrugia Madhusudan Grover

Published in: Gut (2019)

A subset of patients with IBS, especially in PI-IBS, has substantially high faecal PA, greater symptoms, impaired barrier and reduced microbial diversity. Commensal microbiota affects luminal PA that can influence host barrier function.

Keyphrases

irritable bowel syndrome
microbial community
oxidative stress
sleep quality
protein kinase