Anaplastic thyroid cancer cells reduce CD71 levels to increase iron overload tolerance.

Simona D'AprileSimona DenaroAnna Maria PavoneSebastiano GiallongoCesarina GiallongoAlfio DistefanoLucia SalvatorelliFilippo TorrisiRaffaella GiuffridaStefano ForteDaniele TibulloGiovanni Li VoltiGaetano MagroNunzio VicarioRosalba Parenti

Published in: Journal of translational medicine (2023)

The differential tolerance to ferroptosis observed in our study may hold clinical implications, particularly in addressing the unmet therapeutic needs associated with ATC treatment, where resistance to ferroptosis appears more pronounced compared to FTC.

Keyphrases

cell death
cell cycle arrest
induced apoptosis
cell proliferation
combination therapy
replacement therapy