Evaluation of analgesic and anti-inflammatory activity of purine-2,6-dione-based TRPA1 antagonists with PDE4/7 inhibitory activity.

Małgorzata Zygmunt Marietta Ślusarczyk Agnieszka Jankowska Artur Świerczek Adrian Bryła Szczepan Mogilski Grzegorz Kazek Jacek Sapa Elżbieta Wyska Grażyna Chłoń-Rzepa

Published in: Pharmacological reports : PR (2022)

The compounds evaluated in this study represent a new class of derivatives with analgesic and anti-inflammatory activities that involve TRPA1 antagonism and PDE4/7 inhibition.

Keyphrases

anti inflammatory
neuropathic pain
spinal cord