Recent Advances in Transition-metal-catalyzed C-C Bond Formation via C(sp2 )-F Bond Cleavage.

The activation of a carbon-fluorine bond is one of the most challenging topics in modern synthetic organic chemistry due to their low reactivity compared to other carbon-halogen bonds. In this review, we present the recent developments since 2015 on cross-coupling reactions that form C-C bonds via cleavage of C(sp2 )-F bonds. Not only the conventional activation of C(sp2 )-F bonds, but also decarbonylative or carbonyl-retentive cleavage of C(acyl)-F bonds will be introduced. This paper mainly describes new protocols for the formation of C(sp2 )-C(sp3 ), C(sp2 )-C(sp2 ), and C(sp2 )-C(sp) bonds via transition-metal-catalyzed cleavage of C(sp2 )-F bonds.