Identifying epigenetic biomarkers of established prognostic factors and survival in a clinical cohort of individuals with oropharyngeal cancer.

Ryan J LangdonRebecca RichmondHannah R ElliottTom DuddingNabila KazmiChris PenfoldKate IngarfieldKaren HoAndrew BretherickChris HaleyYanni ZengRosie M WalkerMichael PawlitaTim WaterboerTom GauntGeorge Davey SmithMatthew SudermanSteve ThomasAndy NessCaroline Relton

Published in: Clinical epigenetics (2020)

Part of the effect of smoking on survival in those with oropharyngeal cancer may be mediated by methylation at the SPEG gene locus. Replication in data from independent datasets and data from HN5000 with longer follow-up times is needed to confirm these findings.

Keyphrases

prognostic factors
papillary thyroid
dna methylation
squamous cell
electronic health record
genome wide
big data
squamous cell carcinoma
lymph node metastasis
machine learning
copy number
rna seq
data analysis
transcription factor
artificial intelligence