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Chronic intermittent hypoxia triggers cardiac fibrosis: Role of epididymal white adipose tissue senescent remodeling?

Suzain NaushadJonathan GaucherZaineb MezdariMaximin DétraitElise BelaidiYanyan ZhangGuillaume VialSophie BouyonGabor CzibikMaria PiniSahar AldekwerHao LiangVéronique PellouxJudith Aron-WisnewskyRenaud TamisierJean-Louis PépinGeneviève DerumeauxDaigo SawakiClaire Arnaud
Published in: Acta physiologica (Oxford, England) (2024)
Short-term exposure to CIH induces epididymal WAT senescent remodeling and cardiac interstitial fibrosis, the latter being prevented by lipectomy. This finding strongly suggests visceral WAT senescence as a new target to mitigate OSA-related cardiac disorders.
Keyphrases
  • adipose tissue
  • left ventricular
  • insulin resistance
  • endothelial cells
  • obstructive sleep apnea
  • dna damage
  • heart failure
  • type diabetes
  • liver fibrosis
  • positive airway pressure