Chronic intermittent hypoxia triggers cardiac fibrosis: Role of epididymal white adipose tissue senescent remodeling?
Suzain NaushadJonathan GaucherZaineb MezdariMaximin DétraitElise BelaidiYanyan ZhangGuillaume VialSophie BouyonGabor CzibikMaria PiniSahar AldekwerHao LiangVéronique PellouxJudith Aron-WisnewskyRenaud TamisierJean-Louis PépinGeneviève DerumeauxDaigo SawakiClaire ArnaudPublished in: Acta physiologica (Oxford, England) (2024)
Short-term exposure to CIH induces epididymal WAT senescent remodeling and cardiac interstitial fibrosis, the latter being prevented by lipectomy. This finding strongly suggests visceral WAT senescence as a new target to mitigate OSA-related cardiac disorders.