Multiomics Analyses Reveal Microbiome-Gut-Brain Crosstalk Centered on Aberrant Gamma-Aminobutyric Acid and Tryptophan Metabolism in Drug-Naïve Patients with First-Episode Schizophrenia.
Zhuo WangXiuxia YuanZijia ZhuLijuan PangShizhi DingXue LiYulin KangGangrui HeiLiyuan ZhangXiaoyun ZhangShuying WangXuemin JianZhi-Qiang LiChenxiang ZhengXiaoduo FanShaohua HuYongyong ShiXueqin SongPublished in: Schizophrenia bulletin (2023)
This study provides new insights into systematic relationships among genes, metabolism, and the gut microbiota that affect brain functional connectivity, thereby affecting SCZ pathogenesis.