Alterations in melatonin and 5-HT signalling in the colonic mucosa of mice with dextran-sodium sulfate-induced colitis.

Sarah J MacEachernCatherine M KeenanEvangelia PapakonstantinouKeith A SharkeyBhavik Anil Patel

Published in: British journal of pharmacology (2018)

Our data suggest that DSS-induced colitis results in a reduction in melatonin availability and an increase in 5-HT availability, due to a reduction/loss of tryptophan hydroxylase 1 enzyme, 5-HT content and 5-HT transporters. Mechanosensory release was more susceptible to inflammation when compared with chemosensory release.

Keyphrases

oxidative stress
electronic health record
metabolic syndrome
machine learning
ulcerative colitis