Streptoglycerides A-D with a Rare 6/5/5 Tricyclic Ring Skeleton from a Marine Actinomycete Streptomyces species.
Byeoung-Kyu ChoiShin-Young ParkDong-Kug ChoiBora ShinYern-Hyerk ShinDong-Chan OhHwa-Sun LeeHyi-Seung LeeYeon-Ju LeeJong Seok LeeJi Hoon LeeHee Jae ShinPublished in: Organic letters (2018)
Four novel secondary metabolites possessing a unique 6/5/5 tricyclic ring system, streptoglycerides A-D (1-4), were isolated from a marine actinomycete Streptomyces sp. derived from a mangrove sample collected on Kosrae Island. Their structures and absolute configurations were elucidated by spectroscopic data and electronic circular dichroism data. Streptoglyceride C (3) showed a weak inhibitory effect on the production of nitric oxide in BV-2 microglia cells.
Keyphrases
- nitric oxide
- electronic health record
- induced apoptosis
- big data
- inflammatory response
- cell cycle arrest
- ms ms
- molecular docking
- high resolution
- hydrogen peroxide
- neuropathic pain
- data analysis
- nitric oxide synthase
- cell death
- endoplasmic reticulum stress
- spinal cord injury
- mass spectrometry
- molecular dynamics simulations
- genetic diversity