iTRAQ-based quantitative proteomics reveals biomarkers/pathways in psoriasis that can predict the efficacy of methotrexate.

Kexiang YanQ MengH HeH W ZhuZhicheng WangL HanQ HuangZheng-Hua Zhang Nikhil YawalkarH ZhouJ X Xu

Published in: Journal of the European Academy of Dermatology and Venereology : JEADV (2022)

We identified seven differentially expressed and regulated proteins (ANXA6, GPV, FN1, XRCC6, STOM, RPS27A and EZR) as biomarkers to predict MTX efficacy in NF-κB signalling, JAK-STAT pathways, neutrophil degranulation, platelet activation, signalling and aggregation.

Keyphrases

mass spectrometry
high resolution
dna repair
oxidative stress
lps induced
pi k akt
nuclear factor
low dose
dna damage
inflammatory response
cell proliferation