Integrated proteomics spotlight the proteasome as a therapeutic vulnerability in Embryonal Tumors with Multilayered Rosettes.

Matthias DottermuschAli BiabaniTasja LempertzYannis SchumannJelena NavolicShweta GodboleDenise ObrechtStephan FrankMario M DorostkarHannah VoßHartmut SchlüterStefan RutkowskiUlrich SchüllerJulia E Neumann

Published in: Neuro-oncology (2023)

In summary, histomorphology stipulates the proteome signatures of ETMR, and proteasome regulatory proteins are pervasively abundant in these tumors. As validated in vitro, proteasome inhibition poses a promising therapeutic option in ETMR.

Keyphrases

climate change
mass spectrometry
transcription factor
genome wide
gene expression
dna methylation