An immune-molecular hypothesis supporting infectious aetiopathogenesis of Kawasaki disease in children.

Cristina CapittiniGiacomo EmmiSavina MannarinoGrazia BossiRosa Maria DellepianePatrizia SaliceMaria Cristina PietrograndeAnnamaria PasiAnnalisa De SilvestriCarmine TinelliMiryam Martinetti

Published in: European journal of immunology (2018)

The competitive binding between CpG-ODN (single-stranded DNA from pathogens) and HLA-B and HLA-A ligands for the inhibitory Killer Immunoglobulin-like Receptors (KIR)3DL1/2 may lead to possible hypo-sensing of pathogens and ineffective clearance. We observed an overabundance of HLA ligands for inhibitory KIR with three domains in KD subjects.

Keyphrases

gram negative
single molecule
antimicrobial resistance
binding protein
young adults
circulating tumor
dna methylation
nucleic acid
multidrug resistant
gene expression