ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1.
Weihong XieChenqiu ZhangZheyu WangHui ChenTonghui GuTao ZhouYaoxing WuFan XiaMin LiJun WangRenjie JiaoJun CuiShouheng JinPublished in: Autophagy (2023)
; GABARAP: GABA type A receptor-associated protein; GFP: green fluorescent protein; IFN: interferon; IKBKE/IKKi: inhibitor of nuclear factor kappa B kinase subunit epsilon; IRF3: interferon regulatory factor 3; ISG: interferon-stimulated gene; ISRE: IFN-stimulated response element; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MAVS: mitochondrial antiviral signaling protein; MOI: multiplicity of infection; PAMPs: pathogen-associated molecule patterns; RIGI/DDX58: RNA sensor RIG-I; SeV: Sendai virus; siRNA: small interfering RNA; TBK1: TANK binding kinase 1; WT: wild-type; VSV: vesicular stomatitis virus.
Keyphrases
- nuclear factor
- dendritic cells
- toll like receptor
- wild type
- immune response
- protein kinase
- binding protein
- simultaneous determination
- cell death
- protein protein
- oxidative stress
- tyrosine kinase
- amino acid
- quantum dots
- mass spectrometry
- genome wide
- gene expression
- copy number
- cancer therapy
- small molecule
- candida albicans
- dna methylation
- inflammatory response
- solid phase extraction