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Gold and Brønsted Acid Catalyzed Spirocyclization of 2- and 3-Indolyl-Tethered 1,4-Enyne Acetates to Spiro[4,n]alkyl[b]indoles.

Xiaoyu ChenCorentin Antoine BaratayMaddison Elizabeth MarkXin-Fang XuPhilip Wai Hong Chan
Published in: Organic letters (2020)
A synthetic method to prepare spiro[4,n]alkyl[b]indoles (n = 4-6) efficiently that relies on the gold(I) and Brønsted acid mediated spirocyclization of 2- and 3-indolyl-tethered 1,4-enyne acetates at room temperature and open to air is described.
Keyphrases
  • room temperature
  • ionic liquid
  • minimally invasive