What are the challenges involved in the strategies for future antibody-drug conjugate discovery and development for oncology?

Addressing the challenges discussed in this perspective, such as by improving the specificity of targeting cancer cells, the selective site-specific conjugation of cytotoxic drugs to antibodies and developing different strategies to overcome the problem of drug resistance will likely generate a new class of ADCs and bring more value to the concept of ADCs, particularly in the treatment of cancer patients.