Interleukin 27 is increased in carotid atherosclerosis and promotes NLRP3 inflammasome activation.

Ida GregersenØystein SandangerErik T AskevoldEllen Lund SagenKuan YangSverre HolmTurid M PedersenMona SkjellandKirsten Krohg-SørensenTrond Vidar HansenTuva Børresdatter DahlKari OtterdalTerje EspevikPål AukrustArne YndestadBente Halvorsen

Published in: PloS one (2017)

We demonstrate increased levels of IL-27 and IL-27R in patients with carotid atherosclerosis. Our in vitro findings suggest an inflammatory role for IL-27, which can possibly be linked to atherosclerotic disease development.

Keyphrases

nlrp inflammasome
oxidative stress