PD-L1 expression and microsatellite instability (MSI) in cancer of unknown primary site.
João Neif Antonio JuniorDaniel D 'Almeida PretoMaria Eduarda Zanatta Neder LazariniMarcos Alves de LimaMurilo BonatelliGustavo Noriz BerardinelliVinicius Duval da SilvaCéline PinheiroRui Manuel ReisFlavio Mavignier CárcanoPublished in: International journal of clinical oncology (2024)
PD-L1 is expressed in a subset (1/5) of patients with CUP and associated with improved overall survival, while MSI is a rare event. There is a need to explore better the tumor microenvironment as well as the role of immunotherapy to change such a bad clinical outcome.