Performance evaluation of the Ortho VITROS SARS-CoV-2 Spike-Specific Quantitative IgG test by comparison with the surrogate virus neutralizing antibody test and clinical assessment.
Maika TakahashiKaori SaitoTomohiko AiShuko NojiriAbdullah KhasawnehFaith Jessica ParanYuki HoriuchiSatomi TakeiTakamasa YamamotoMitsuru WakitaMakoto HikiTakashi MiidaToshio NaitoKazuhisa TakahashiYoko TabePublished in: PloS one (2023)
Although the automated quantitative immunoassay VITROS S-IgG showed a reasonable correlation with sVNT antibodies, there is some discrepancy between Vitros S-IgG and cPass sVNT in milder cases. Thus, VITROS S-IgG can be a useful diagnostic tool in assessing the immune responses to vaccination and herd immunity. However, careful analysis is necessary to interpret the results.