Normal preoperative endogenous testosterone levels predict prostate cancer progression in elderly patients after radical prostatectomy.
Antonio Benito PorcaroAndrea PanunzioAlberto BianchiClara CerratoSebastian GallinaEmanuele SerafinGiovanni MazzucatoStefano VidiriDamiano D'AiettiRossella OrlandoDavide BrusaMatteo BrunelliSalvatore SiracusanoVincenzo PagliaruloMaria Angela CerrutoAlessandro TafuriAlessandro AntonelliPublished in: Therapeutic advances in urology (2023)
In elderly patients, normal preoperative ET independently predicted PCa progression. Elderly patients with normal ET progressed more rapidly than controls, suggesting that longer exposure time to high-grade tumors could adversely impact sequential cancer mutations, where normal ET is not anymore protective on disease progression.