Transcriptional Landscape of Enhancer RNAs in Peripheral Blood Mononuclear Cells from Patients with Systemic Lupus Erythematosus.

Gangqiang GuoHuijing WangXinya TongLele YeXinyu ShiSu FangYa HuFei HanChaosheng ChenNing DingBofeng SuXiangyang XueHuidi Zhang

Published in: Journal of inflammation research (2022)

This study unraveled the transcriptional landscape of eRNAs, eRNA-related TFs, and super-enhancers in PBMCs from SLE patients and HCs. We identified a panel of SLE-relevant eRNAs, providing potential targets in SLE pathogenesis.

Keyphrases

systemic lupus erythematosus
disease activity
end stage renal disease
transcription factor
gene expression
ejection fraction
chronic kidney disease
newly diagnosed
single cell
prognostic factors
peritoneal dialysis
risk assessment
patient reported outcomes
oxidative stress