Comprehensive methylome sequencing reveals prognostic epigenetic biomarkers for prostate cancer mortality.

Ruth PidsleyDilys LamWenjia QuTimothy J PetersPhuc-Loi LuuDarren KorbieClare StirzakerRoger J DalyPhillip StrickerJames G KenchLisa G HorvathSusan J Clark

Published in: Clinical and translational medicine (2022)

Our study provides detailed methylome maps of non-lethal and lethal prostate cancer and identifies novel genic regions that distinguish these patient groups. Inclusion of our DNA methylation biomarkers with existing clinicopathological measures improves prognostic models of prostate cancer mortality, and holds promise for clinical application.

Keyphrases

prostate cancer
dna methylation
radical prostatectomy
genome wide
cardiovascular events
gene expression
risk factors
case report
type diabetes
machine learning
big data
copy number