Spatially constrained kinetic modeling with dual reference tissues improves 18F-flortaucipir PET in studies of Alzheimer disease.

Yun ZhouShaney FloresSyahir MansorRuss C HornbeckZhude TuJoel S PerlmutterBeau AncesJohn C MorrisRobert J GroplerTammie L S Benzinger

Published in: European journal of nuclear medicine and molecular imaging (2021)

Using a spatially constrained kinetic model with dual reference tissues significantly improved quantification of relative perfusion and tau binding. Cerebellum and CS are the suggested reference tissues to estimate R1 and DVR, respectively, for dynamic 18F-flortaucipir PET studies. Cerebellum-based SUVREP and CS-based SUVRLP may be used to simplify 18F-flortaucipir PET study.

Keyphrases

pet ct
positron emission tomography
gene expression
computed tomography
pet imaging
case control
mild cognitive impairment
magnetic resonance
binding protein
cerebrospinal fluid
transcription factor