Aspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N-ERD based on urinary 15-oxo-ETE and LTE 4 excretion.

Lucyna MastalerzGabriela TrądPiotr SzatkowskiAdam ĆmielAnna GieliczRadosław KacorzykHanna PluteckaJoanna SzaleniecAgnieszka Gawlewicz-MroczkaBogdan JakiełaMarek Sanak

Published in: Allergy (2024)

We confirmed 15-oxo-ETE as a second to cysteinyl leukotrienes biomarker of N-ERD. An index based on these eicosanoids corrected for sex and Lund-Mackay score has a similar diagnostic value as gold standard oral aspirin challenge in the studied group of patients with asthma.

Keyphrases

low dose
cardiovascular events
antiplatelet therapy
chronic obstructive pulmonary disease
lung function
drug induced
coronary artery disease
silver nanoparticles
allergic rhinitis
atrial fibrillation