Aspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N-ERD based on urinary 15-oxo-ETE and LTE 4 excretion.
Lucyna MastalerzGabriela TrądPiotr SzatkowskiAdam ĆmielAnna GieliczRadosław KacorzykHanna PluteckaJoanna SzaleniecAgnieszka Gawlewicz-MroczkaBogdan JakiełaMarek SanakPublished in: Allergy (2024)
We confirmed 15-oxo-ETE as a second to cysteinyl leukotrienes biomarker of N-ERD. An index based on these eicosanoids corrected for sex and Lund-Mackay score has a similar diagnostic value as gold standard oral aspirin challenge in the studied group of patients with asthma.