Methylation analysis by targeted bisulfite sequencing in large for gestational age (LGA) newborns: the LARGAN cohort.
Tamara Carrizosa-MolinaNatalia Casillas-DíazIris Pérez-NadadorClaudia Vales-VillamarínMiguel Ángel López-MartínezRosa Riveiro-ÁlvarezLarry WilhelmRita Cervera-JuanesCarmen GarcésAlejandro LomnicziLeandro Soriano-GuillénPublished in: Clinical epigenetics (2023)
Our study identified several DMCs/DMRs in association with fetal overgrowth. The use of cord blood as a material for the identification of DNA methylation biomarkers gives us the possibility to perform follow-up studies on the same patients as they grow. These studies will not only help us understand how the methylome responds to continuum postnatal growth but also link early alterations of the DNA methylome with later clinical markers of growth and metabolic fitness.
Keyphrases
- cord blood
- gestational age
- dna methylation
- birth weight
- ejection fraction
- preterm birth
- end stage renal disease
- newly diagnosed
- genome wide
- pregnant women
- gene expression
- body composition
- physical activity
- case control
- patient reported outcomes
- cancer therapy
- single cell
- circulating tumor
- bioinformatics analysis
- data analysis