Development, Validation, and Stability Assessment Application of RP-HPLC-DAD Method for Quantification of Ampicillin in Total Parenteral Nutrition Admixtures.

Maciej StawnyAleksandra GostyńskaKatarzyna DettlaffAnna JelińskaMarta KościelniakMagdalena Ogrodowczyk

Published in: Antibiotics (Basel, Switzerland) (2019)

The degradation of AMP in the TPN admixtures occurred according to first order kinetics. The degradation rate was high and dependent on the composition of the mixture and the storage conditions (t0.5 varied from 142.44 h to 300.45 h).

Keyphrases

ms ms
simultaneous determination
protein kinase
high performance liquid chromatography
solid phase extraction
high resolution