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Studies on the Role of circRNAs in Osteoarthritis.

Wei WuJun Zou
Published in: BioMed research international (2021)
We found that most articles about circRNAs regulating OA in the recent 5 years focused on the mechanism, especially the absorption effect of circ-miRNA as sponges in the recent 2 years, while most of the articles about their functions addressed ECM and PI3K, AKT, and mTOR signaling pathways. Future studies might focus on the functions of circRNAs, and circRNA VWF, with preferable functions, interactions, and involvement, can be used as a biological indicator to detect OA in clinical practice.
Keyphrases
  • pi k akt
  • signaling pathway
  • cell proliferation
  • knee osteoarthritis
  • clinical practice
  • cell cycle arrest
  • case control
  • rheumatoid arthritis
  • extracellular matrix
  • endoplasmic reticulum stress