Chitosan decorated oleosomes loaded propranolol hydrochloride hydrogel repurposed for Candida albicans -vaginal infection.
Moaz A EltabeebMenna M AbdellatifMohamed A El-NabarawiMahmoud H TeaimaMohammed I A HamedKhaled M DarwishMariam HassanAhmed Me HamdanRaghda Rabe HamedPublished in: Nanomedicine (London, England) (2024)
Aim: Our investigation aims to estimate the antifungal effect of propranolol hydrochloride (PNL). Methods: Oleosomes (OLs) were fabricated by thin-film hydration and evaluated for entrapment efficiency (EE%), particle size (PS), polydispersity index (PDI), zeta potential (ZP), and amount of drug released after 6 h Q6h (%). Results: The optimal OL showed a rounded shape with optimum characteristics. The ex-vivo permeation and confocal laser scanning microscopy verified the prolonged release and well deposition of PNL-loaded OLs-gel. The in-silico assessment demonstrated the good stability of PNL with OLs' ingredients. In vivo evaluations for PNL-loaded OLs-gel showed a good antifungal impact against Candida albicans with good safety. Conclusion: This work highlights the potential of PNL-loaded OLs-gel as a potential treatment for candida vaginal infection.
Keyphrases
- candida albicans
- wound healing
- drug delivery
- biofilm formation
- cancer therapy
- hyaluronic acid
- high resolution
- optical coherence tomography
- staphylococcus aureus
- emergency department
- single molecule
- smoking cessation
- gold nanoparticles
- electronic health record
- replacement therapy
- highly efficient
- adverse drug
- climate change