Unfolded Von Willebrand Factor Binds Protein S and Reduces Anticoagulant Activity.

Martha M S SimMolly Y MollicaHammodah R AlfarMelissa HollifieldDominic W ChungXiaoyun FuSiva GandhapudiDaniëlle M CoenenKanakanagavalli Shravani PrakhyaDlovan F D MahmoodMeenakshi BanerjeeChi PengXian LiAlice C ThorntonJames Z PorterfieldJamie L SturgillGail A SievertMarietta Barton-BaxterZe ZhengKenneth S CampbellJerold G WoodwardJosé A LópezSidney W WhiteheartBeth A GarvyJeremy P Wood

Published in: bioRxiv : the preprint server for biology (2024)

Von Willebrand Factor (VWF) binds Protein S (PS) in a shear-dependent manner, reducing the free PS pool and its anticoagulant activity.The PS/VWF complex forms under turbulent flow conditions, is stable in whole blood, and localizes to growing platelet thrombi.

Keyphrases

venous thromboembolism
atrial fibrillation
protein protein
amino acid
endoplasmic reticulum stress