Electrochemical Deconstructive and Ring-Expansion Functionalization of Unstrained Cycloalkanols.
Lulu ZhaoPengwei HuJian TianXiao ZhangChao YangLin GuoWujiong XiaPublished in: Organic letters (2024)
An efficient and sustainable electrochemical method for the synthesis of cyclic ethers and acyclic aldehydes from alkanols has been reported. This strategy has been successfully applied to cycloalkanols bearing different ring sizes and different types of nucleophiles. In addition, mechanistic investigations show that the reactions undergo sequential processes, including anodic oxidation, β-scission, and nucleophilic addition. This method provides a new synthetic approach to constructing cyclic ethers and terminal aldehydes from cycloalkanols and nucleophiles.