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Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development.

Wencheng PuJiao LiYuanyuan ZhengXianyan ShenXin FanJian-Kang ZhouJuan HeYulan DengXuesha LiuChun WangShengyong YangQiang ChenLunxu LiuGuolin ZhangYu-Quan WeiYong Peng
Published in: Hepatology (Baltimore, Md.) (2018)
Experimental evidence suggests that Pin1 inhibition by API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development, revealing the mechanism of Pin1-mediated miRNA biogenesis and unequivocally supporting API-1 as a drug candidate for HCC therapy, especially for Pin1-overexpressing, extracellular signal-regulated kinase-activated HCC. (Hepatology 2018).
Keyphrases
  • signaling pathway
  • transcription factor
  • emergency department
  • bone marrow
  • mesenchymal stem cells
  • crystal structure
  • drug induced