Targeting Pin1 by inhibitor API-1 regulates microRNA biogenesis and suppresses hepatocellular carcinoma development.
Wencheng PuJiao LiYuanyuan ZhengXianyan ShenXin FanJian-Kang ZhouJuan HeYulan DengXuesha LiuChun WangShengyong YangQiang ChenLunxu LiuGuolin ZhangYu-Quan WeiYong PengPublished in: Hepatology (Baltimore, Md.) (2018)
Experimental evidence suggests that Pin1 inhibition by API-1 up-regulates miRNA biogenesis by retaining active XPO5 conformation and suppresses HCC development, revealing the mechanism of Pin1-mediated miRNA biogenesis and unequivocally supporting API-1 as a drug candidate for HCC therapy, especially for Pin1-overexpressing, extracellular signal-regulated kinase-activated HCC. (Hepatology 2018).