Aquaporin 9 is involved in CRC metastasis through DVL2-dependent Wnt/β-catenin signaling activation.

Yiting LiuQianling GaoXingzhi FengGuanxing ChenXuefei JiangDaici ChenZi-Huan Yang

Published in: Gastroenterology report (2023)

Collectively, our study revealed the important role of AQP9 in regulating DVL2 stabilization and Wnt/β-catenin signaling to promote CRC metastasis. Targeting the NEDD4L-AQP9-DVL2 axis might have therapeutic usefulness in metastatic CRC treatment.

Keyphrases

cell proliferation
stem cells
squamous cell carcinoma
small cell lung cancer
combination therapy
smoking cessation