Stromal derived factor-1 mediates the lung regenerative effects of mesenchymal stem cells in a rodent model of bronchopulmonary dysplasia.

Joel ReiterShelley DrummondIbrahim SammourJian HuangVictoria FloreaPolliana DornasJoshua M HareClaudia O RodriguesKaren C Young

Published in: Respiratory research (2017)

The therapeutic benefits of MSCs in neonatal HILI are in part mediated by SDF-1, through anti-inflammatory and angiogenesis promoting mechanisms. Therapies directly targeting this chemokine may provide a novel strategy for the treatment of BPD.

Keyphrases

mesenchymal stem cells
umbilical cord
bone marrow
anti inflammatory
cell therapy
stem cells
endothelial cells
combination therapy
tissue engineering