Differential response to neoadjuvant hormonal therapy in prostate cancer: Predictive morphological parameters and molecular markers.
Xueli WangMei QiJing ZhangXiubin SunHongwei GuoYu PangQian ZhangXinyi ChenRuifeng ZhangZhiyan LiuLong LiuXiaomeng HaoBo HanPublished in: The Prostate (2019)
Our study suggested that the presence of tumor cribriform growth pattern, macronucleoli, ductal adenocarcinoma differentiation, and PTEN loss in needle biopsies are of value in predicting tumor response to NHT regimen. Multivariate logistic regression analysis revealed the performance of combined pathological indicators in predicting DR response was better than that of model based on individual factor alone.
Keyphrases
- prostate cancer
- locally advanced
- ultrasound guided
- radical prostatectomy
- squamous cell carcinoma
- cell proliferation
- lymph node
- type diabetes
- stem cells
- single cell
- radiation therapy
- polycystic ovary syndrome
- insulin resistance
- mesenchymal stem cells
- editorial comment
- single molecule
- signaling pathway
- replacement therapy
- cell therapy