Heritability in genetic heart disease: the role of genetic background.

Joeri A JansweijerKarin Y van Spaendonck-ZwartsMichael W T Tanckvan J Peter TintelenImke ChristiaansJasper van der SmagtAlexa VermeerJ Martijn BosArthur J MossHeikki SwanSylvia G PrioriAnnika RydbergJacob Tfelt-HansenMichael J AckermanIacopo OlivottoPhilippe CharronJuan R GimenoMaarten van den BergArthur A M WildeYigal M Pinto

Published in: Open heart (2019)

Our study confirms previously found robust heritability for electrical traits like QTc in LQTS, and adds information on low or lacking heritability for structural traits in heritable cardiomyopathies. This may steer the search for genetic modifiers in heritable cardiac disease.

Keyphrases

genome wide
copy number
dna methylation
left ventricular
pulmonary hypertension
heart failure
gene expression
health information
social media