Depletion of FoxP3+ Tregs improves control of larval Echinococcus multilocularis infection by promoting co-stimulation and Th1/17 immunity.

Junhua WangStephan MüllerRenyong LinMyriam SiffertDominique A VuittonHao WenBruno Gottstein

Published in: Immunity, inflammation and disease (2017)

FoxP3+ Tregs appear as one of the key players in immune regulatory processes favoring (i) metacestode survival by inhibiting the maturation potential of co-stimulatory activity and (ii) T cell exhaustion (suppressing Th1/Th17-type immune responses). We showed as well that prospectively, targeting FoxP3+ Tregs could be an option to develop an immunotherapy against AE.

Keyphrases

regulatory t cells
immune response
dendritic cells
signaling pathway
toll like receptor
risk assessment
drug delivery
inflammatory response
aedes aegypti
human health
climate change
zika virus