Concentration of voxelotor in sickle cell disease can be estimated using electrophoresis and high-performance liquid chromatography.

Susanna A CurtisElana FriedmanCaterina MinnitiAnnie Nguyen DangMira PochronMerin ThomasJaime BetancourtLeena VattappallyAndrew CrouchJulissa MoralesSean T Campbell

Published in: American journal of clinical pathology (2024)

Thus, peak splitting CZE and HPLC can be used to estimate voxelotor concentration.

Keyphrases

high performance liquid chromatography
sickle cell disease
simultaneous determination
tandem mass spectrometry
solid phase extraction
mass spectrometry
ms ms
liquid chromatography
high resolution