Bacterial neuraminidase-mediated erythrocyte desialylation provokes cell surface aminophospholipid exposure.

Syed M QadriDavid A DonkorIshac NazyDonald R BranchWilliam P Sheffield

Published in: European journal of haematology (2018)

Collectively, our data reveal that alteration of erythrocyte sialylation status by bacterial neuraminidase favors eryptotic cell death, an effect potentially contributing to reduced erythrocyte lifespan and anemia in sepsis.

Keyphrases

cell surface
cell death
chronic kidney disease
intensive care unit
acute kidney injury
electronic health record
genome wide
septic shock
big data
single cell
machine learning
gene expression
cell cycle arrest
dna methylation
data analysis