Effects of stress-related peptides on chloride secretion in the mouse proximal colon.

Sumei LiuAaron KaroSita AgterbergHoward HuaAditi Bhargava

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2020)

The findings revealed sex differences in baseline colonic secretion and responses to stress-related peptides. CRF2 receptors play a more prominent role in colonic secretion in male mice. The greater baseline secretion and responses to UCNs may contribute to the higher prevalence of diarrhea-predominant IBS in males.

Keyphrases

irritable bowel syndrome
risk factors
ulcerative colitis
clostridium difficile