Mapping the Immune Landscape in Metastatic Melanoma Reveals Localized Cell-Cell Interactions That Predict Immunotherapy Response.
Asier AntoranzYannick Van HerckMaddalena Maria BolognesiSeodhna M LynchArman RahmanWilliam M GallagherVeerle BoecxstaensJean-Christophe MarineGiorgio CattorettiJoost J van den OordFrederik De SmetOliver BechterFrancesca Maria BosisioPublished in: Cancer research (2022)
This study shows that spatial characterization can address the challenge of finding efficient biomarkers, revealing that localization of macrophages and T cells in melanoma predicts patient response to ICI. See related commentary by Smalley and Smalley, p. 3198.