WNT: an unexpected tumor suppressor in medulloblastoma.
Branavan ManoranjanAshley A AdileChitra VenugopalSheila K SinghPublished in: Molecular & cellular oncology (2020)
Medulloblastoma (MB) represents the most common malignant pediatric brain tumor and is defined by four molecular subgroups with WNT MB having the most favorable prognosis. Our work provides a rational therapeutic option in which the protective effects of WNT-driven MBs may be augmented in Group 3 and 4 MB.