Natural history of patients with Leber hereditary optic neuropathy-results from the REALITY study.

Patrick Yu-Wai-ManNancy J NewmanValerio CarelliChiara La MorgiaValérie BiousseFrancesco M BandelloCatherine Vignal ClermontLorena Castillo CampilloStephanie LeruezMark L MosterDean M CestariRod ForoozanAlfredo SadunRustum KaranjiaNeringa JurkuteLaure BlouinNancy J NewmanJosé-Alain Sahelnull null

Published in: Eye (London, England) (2021)

Amongst LHON patients with the three primary mtDNA mutations, adult patients with the m.11778G>A ND4 mutation had the worst visual outcomes, consistent with prior reports.

Keyphrases

copy number
emergency department
type diabetes
metabolic syndrome
dna methylation
adipose tissue
skeletal muscle
genome wide