Respiratory effects of biased-ligand oliceridine in older volunteers: a pharmacokinetic-pharmacodynamic comparison with morphine.

Pieter SimonsRutger van der SchrierMaarten van LemmenSimone JansenKiki Wk KuijpersMonique van VelzenElise SartonTodd NicklasCathy MichalskyMark A DemitrackMichael FosslerErik OlofsenMarieke NiestersAlbert Dahan

Published in: Anesthesiology (2022)

Oliceridine and morphine differ in their respiratory pharmacodynamics with a more rapid onset and offset of respiratory depression for oliceridine and smaller magnitude of respiratory depression over time.

Keyphrases

depressive symptoms
respiratory tract
sleep quality
physical activity