FN (Fibronectin)-Integrin α5 Signaling Promotes Thoracic Aortic Aneurysm in a Mouse Model of Marfan Syndrome.

Minghao Chen Cristina Cavinato Jens Hansen Keiichiro Tanaka Pengwei RenAbdulrahman HassabDavid S Li Eric Youshao George Tellides Ravi Iyengar Jay D Humphrey Martin Alexander Schwartz

Published in: Arteriosclerosis, thrombosis, and vascular biology (2023)

FN-integrin α5 signaling is a significant driver of TAA in the mgR mouse model. This pathway thus warrants further investigation as a therapeutic target.

Keyphrases

mouse model
aortic aneurysm
spinal cord
cell migration
case report