Rapid reversal of innate immune dysregulation in blood of patients and livers of humanized mice with HCV following DAA therapy.
Matthew A BurchillJustin A RobyNanette CrochetMegan Wind-RotoloAmy E StoneMichael G EdwardsRachael J DranMichael S KrissMichael GaleHugo R RosenPublished in: PloS one (2017)
Collectively, our data demonstrate that the rapid viral clearance following treatment with DAAs results in the rebalancing of innate antiviral response in both the peripheral blood and the liver as well as enhanced antiviral signaling within previously infected hepatocytes.
Keyphrases
- peripheral blood
- innate immune
- end stage renal disease
- immune response
- newly diagnosed
- chronic kidney disease
- ejection fraction
- hepatitis c virus
- peritoneal dialysis
- stem cells
- loop mediated isothermal amplification
- mesenchymal stem cells
- human immunodeficiency virus
- patient reported outcomes
- high fat diet induced
- skeletal muscle
- quantum dots
- replacement therapy
- sensitive detection