EGF/EGFR upregulates and cooperates with Netrin-4 to protect glioblastoma cells from DNA damage-induced senescence.

Li LiYulun HuangYuge GaoTengfei ShiYunyun XuHuini LiMarko HyytiäinenJorma Keski-OjaQiuying JiangYizhou HuZhimin Du

Published in: BMC cancer (2018)

This study indicates that EGF/EGFR regulates and cooperates with NTN4 in DNA damage resistance in GBM. Therefore, our findings provide a potential therapeutic target for GBM.

Keyphrases

dna damage
small cell lung cancer
epidermal growth factor receptor
dna repair
oxidative stress
tyrosine kinase
growth factor
diabetic rats
high glucose
endothelial cells
drug induced
stress induced
human health