Biomarker Changes in Response to Tofacitinib Treatment in Patients with Polyarticular Course Juvenile Idiopathic Arthritis.
Ekemini Akan OgbuHermine I BrunnerEsraa M EloseilyYonatan Butbul AvielKabita NandaHeinrike SchmelingHeather ToryYosef UzielDiego Oscar ViolaDawn M WaheziStacey E TarvinAlyssa SprolesChen ChenNicolino RupertoBin HuangAlexei GromSherry Thorntonnull nullPublished in: Arthritis care & research (2024)
Among the CBB included, only resistin was significantly associated with treatment response, and no CBB was identified that forecasts JIA improvement after initiation of tofacitinib. The association of HLA-B27 positivity with lower response to tofacitinib in JIA is intriguing and merits further study.