Frequency of heterozygous germline pathogenic variants in genes for Fanconi anemia in patients with non-BRCA1/BRCA2 breast cancer: a meta-analysis.

Blanche P AlterAna F Best

Published in: Breast cancer research and treatment (2020)

Heterozygous pathogenic variants in FANCN/PALB2 and possibly FANCJ/BRIP1 may account for 1-2% of familial non-BRCA1/2 breast cancer cases and 0.5-1% of unselected cases. Genetic counseling and testing may be suggested for unaffected relatives.

Keyphrases

breast cancer risk
early onset
copy number
genome wide
dna repair
dna methylation
dna damage
oxidative stress
gene expression
iron deficiency
men who have sex with men
hiv testing
genome wide analysis