Preclinical characterization of [18F]T-008, a novel PET imaging radioligand for cholesterol 24-hydroxylase.
Tatsuki KoikeCristian C ConstantinescuShuhei IkedaToshiya NishiEiji SunaharaMaki MiyamotoPatricia ColeOlivier BarretDavid AlagilleCaroline PapinThomas MorleyKrista FowlesJohn SeibylGilles TamagnanTakanobu KuroitaPublished in: European journal of nuclear medicine and molecular imaging (2021)
The preclinical in vitro and in vivo evaluation of labeled T-008 demonstrates that [18F]T-008 is suitable for imaging CH24H in the brain and warrants further studies in humans.
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