Monoaminergic Genetic Variants, Prefrontal Cortex-Amygdala Circuit, and Emotional Symptoms in Children With ADHD: Exploration Based on the Gene-Brain-Behavior Relationship.
Lu LiuQihua ZhaoXiaoyan YuDefeng XuHaimei LiNing JiZhaomin WuJia ChengYi SuQingjiu CaoLi SunQiujin QianYufeng WangPublished in: Journal of attention disorders (2020)
Objective: This study aimed to explore the association between monoaminergic genetic variants and emotional lability (EL) symptoms in children with ADHD. In addition, genetic effects on prefrontal cortex (PFC)-amygdala functional connectivity (FC) were investigated. Method: Children with ADHD and controls were genotyped for five monoaminergic genetic variants and were evaluated for EL symptoms. Imaging genetic exploration was conducted with previously reported aberrant PFC-amygdala resting-state functional connectivities (RSFCs) as target features. Results: A genotypic effect on EL symptoms was only found for NET1-rs3785143, indicating higher EL symptoms in TT genotype carriers than in C-allele carriers. Imaging genetic analyses indicated a marginal effect of NET1-rs3785143 on ADHD-altered FC between the superficial amygdala (SFA) and middle frontal gyrus (MFG). Mediation analysis suggested potential effects of NET1-rs3785143 via RSFC (SFA-MFG) on EL. Conclusion: NET1 variants might participate in the pathogenesis of EL in children with ADHD by influencing the function of the PFC-amygdala circuit.
Keyphrases
- functional connectivity
- resting state
- prefrontal cortex
- attention deficit hyperactivity disorder
- autism spectrum disorder
- working memory
- young adults
- copy number
- genome wide
- sleep quality
- high resolution
- multiple sclerosis
- gene expression
- brain injury
- dna methylation
- physical activity
- depressive symptoms
- photodynamic therapy
- cerebral ischemia
- temporal lobe epilepsy